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Li Y, Welm B, Podsypanina K, Huang S, Chamorro M, Zhang X, Rowlands T, Egeblad M, Cowin P, Werb Z, Tan LK, Rosen JM, Varmus HE (2003). Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells. Proc Natl Acad Sci USA. 100;15853-15858.
Pao W, Miller V, Zakowski M, Doherty J, Politi K, Sarkaria I, Singh B, Heelan R, Rusch V, Fulton L, Mardis E, Kupfer D, Wilson R, Kris M, Varmus, HE. (2004) EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci USA. 101;13306-13311.
Pao, W, Wang, TY, Riely, GJ, Miller, VA, Pan, Q, Ladanyi, M, Zakowski, MF, Heelan, RT, Kris, MG, Varmus, HE (2005) KRAS mutations and primary resistance of lung adenocarcinomas for gefitinib or erlotinib. PLoS Medicine 2: e17.
Huang, S, Li, Y, Chen, Y, Podsypanina, K, Chamorro, M, Olshen, AB, Desai, KB, Tann, A, Petersen, D, Green, JE, and Varmus, HE (2005) Changes in gene expression during the development of mammary tumors in MMTV-Wnt-1 transgenic mice BMC Mol Biol 6: R84.
Carter, TA, Wodicka, LM, Shah, NP, Velasco, AM, Fabian, MA, Treiber, DK, Milanov, ZV, Atteridge, CE, Biggs III, WE, Edeen, PT, Floyd, M, Ford, JM, Grotzfeld. RM, Herrgard, S, Insko, DE, Mehta, SA, Patel, HK, Pao, W, Sawyers, CL, Varmus, HE, Zarrinkar, PP, and Lockhart, DJ (2005) Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases. Proc Natl Acad Sci U S A 102: 11011-16.
Pao, W., Miller, V.A., Politi, K., Riely, G.J., Somwar, R., Zakowski. M.F., Kris, M.G., Varmus, H.E. (2005) Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med 2:3 e73.
Politi, K, Zakowski, MF, Fan, P, Schonfeld, EA, Pao, W and Varmus, HE (2006) Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors Genes Dev. 20: 1496-1510.
Du Z, Podsypanina K, Huang S, McGrath A, Toneff MJ, Bogoslovskaia E, Zhang X, Moraes RC, Fluck M, Allred DC, Lewis MT, Varmus HE, Li Y. (2006) Introduction of oncogenes into mammary glands in vivo with an avian retroviral vector initiates and promotes carcinogenesis in mouse models. Proc Natl Acad Sci U S A. 46:17396-401.
Marks, JL, McLellan, MD, Zakowski, MF, Lash, AE, Kasai, Y, Broderick, S, Sarkaria, IS, Pham, D, Singh, B, Miner, TL, Fewell, GA, Fulton, LL, Mardis, ER, Wilson, RK, Kris, MG, Rusch, RW, Varmus, HE, Pao, W. (2007) Mutational Analysis of EGFR and Related Signaling Pathway Genes in Lung Adenocarcinomas Identifies a Novel Somatic Kinase Domain Mutation in FGFR4. PLoS One 2:e426.
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