Biopsy
If the doctor believes there is any cause for concern about a particular mole or patch of skin, he or she will perform a biopsy, in which all or part of the growth is surgically removed. This is usually done in the doctor's office using a local anesthetic. The skin that is removed is examined under a microscope by a pathologist to determine if any cancer is present.
Imaging Tests
If cancer is found to be present in a mole or patch of skin, the doctor may perform additional diagnostic tests, including blood tests, a chest x-ray, or other diagnostic imaging tests such as MRI (magnetic resonance imaging) and CT (computed tomography). Information from these tests will help the doctor determine the stage (extent) of the disease and select the appropriate treatment.