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Faculty Positions for physician-scientists in Translational Oncology

Over the past five years, cancer research has entered an exciting new era in which a number of highly effective, nontoxic targeted cancer therapies have been developed based on improved understanding of the molecular underpinnings of cancer. Examples of therapies include trastuzumab (Herceptin®) for breast cancer, imatinib (Gleevec®) for certain leukemias and sarcomas, erlotinib (Tarceva®) for lung cancer, and sunitinib (Sutent®) for kidney cancer, to name a few. The Human Oncology and Pathogenesis Program (HOPP) at Memorial Sloan-Kettering Cancer Center is a newly established program created to capitalize on the opportunities and address the challenges presented by this era. Successful translation of molecular insights into clinical trials requires that teams of physician-scientists with diverse clinical and scientific training work together. The mission of HOPP is to bring such individuals together under one roof and provide the resources and infrastructure required to achieve this goal.

2008 Geoffrey Beene Cancer Research Retreat
2008 Geoffrey Beene Cancer Research Retreat
The 2008 Geoffrey Beene Cancer Research Retreat was held in May

Over the past year we have been successful in recruiting several outstanding young physician-scientists to join us in HOPP, such that as of December 2007, we already had nine faculty members. Together, these individuals bring expertise in prostate, breast, lung, and thyroid cancers, as well as sarcoma, melanoma, glioblastoma, and leukemia, and have clinical training in oncology, hematology, radiation oncology, endocrinology, and pathology. We have also established infrastructure within HOPP to conduct molecular profiling studies of patient material on a routine basis. This information will guide the appropriate use of new molecularly targeted therapies in the clinical trials conducted at Memorial Sloan-Kettering.

The success of HOPP depends on philanthropic support to bring highly talented individuals from top medical schools and cancer centers from around the country. That support is particularly critical now, as new faculty must purchase equipment and hire research staff during the initial years of their appointment before they can begin to attract Federal support for their work from the National Cancer Institute and other funding agencies. The investments made so far are already beginning to pay off. Clinical trials of new molecularly targeted drugs for prostate cancer, lung cancer, and melanoma -- all based on discoveries made in the laboratories of HOPP faculty -- are currently underway at Memorial Sloan-Kettering.

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