Human Oncology and Pathogenesis Program Timothy A. Chan James A. Fagin Members of the Laboratory Publications William L. Gerald Marc Ladanyi Ross L. Levine Ingo K. Mellinghoff William Pao Charles L. Sawyers David B. Solit Research > Memorial Hospital Research > Human Oncology and Pathogenesis Program > James A. Fagin Publications Kimura E, Nikiforova M, Zhu Z, Knauf J, Nikiforov YE, Fagin JA. High prevalence of BRAF mutations in thyroid cancer: Genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. Cancer Res. 2003, 63,1454-1457. Mitsutake N, Knauf JA, Mitsutake S, Mesa Jr C, Zhang L and Fagin JA. Conditional BRAFV600E expression induces DNA synthesis, apoptosis, dedifferentiation and chromosomal instability in thyroid PCCL3 cells. 2005. Cancer Research. 65(6):2465-73. Ciampi R, Knauf JA, Kerler, R, Gandhi M, Zhu Z, Nikiforova M, Rabes H, Fagin JA, Nikiforov YE. Oncogenic AKAP9-BRAF fusion: a novel mechanism of MAP kinase pathway activation in radiation-induced and sporadic thyroid cancer. 2005. J Clin Invest. 115(1):94-101. Knauf JA, Ma X, Smith EP, Zhang L, Mitsutake N, Liao X, Refetoff S, Nikiforov YE, Fagin JA. Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation. Cancer Research. 2005. 65(10):4238-45. Mitsutake N, Miyagishi M, Mitsutake S, Akeno N, Mesa Jr. C, Knauf JA, Zhang L, Taira K, Fagin JA. BRAF mediates RET/PTC-induced MAPK activation in thyroid cells: functional support for requirement of the RET/PTC-RAS-BRAF pathway in papillary thyroid carcinogenesis. Endocrinology. 2006. 147 (2):1014-9. Ouyang B, Knauf JA, Smith EK, Zhang L, Ramsey T, Yussuf N, Batt D, Fagin JA. Inhibitors of Raf kinase activity block growth of thyroid cancer cells with RET/PTC or BRAF mutations in vitro and in vivo. Clin Cancer Research. 2006 12 (6):1785-93. Mesa Jr C, Mitsutake N, Knauf JA, Sartor M, Medvedovic M, Tomlinson C, Mirza M, Weber G, Fagin JA. Conditional activation of the RET/PTC3 and B-RAFV600E oncoproteins in thyroid cells is associated with unique patterns of gene expression that predict distinct functional properties and a preferential role of BRAF in extracellular matrix remodeling. Cancer Research. 2006. Jul 1;66(13):6521-9. Knauf JA, Ouyang B, Knudsen E, Fukasawa K, Babcock, Fagin JA. Oncogenic RAS induces accelerated transition through G2/M and defects in the G2 DNA damage and mitotic spindle checkpoints. J. Biol Chem. 2006. 281 (7): 3800-9

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