Newly Diagnosed?
We Can Help Getting the correct diagnosis and the most appropriate treatment from the start is crucial 
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Virtually all forms of nonmetastatic GTD can be cured with prompt management. Even advanced GTD can be extremely responsive to carefully monitored chemotherapy.
Effective multidrug chemotherapy regimens have vastly improved the outlook for patients with metastatic disease, with cure rates currently as high as 80 to 90 percent. At Memorial Sloan-Kettering Cancer Center, we have one of the most sophisticated programs in the world for the diagnosis and management of women with high-risk GTD.
The two primary approaches for treating GTD are surgery and chemotherapy. Radiation therapy is rarely used, and is usually reserved as part of combination treatment for patients whose GTD has spread to the brain.
Surgery
Hydatidiform moles are most commonly removed by dilation and suction curettage (D&C), which is usually performed as an outpatient procedure. During this procedure, your doctor enlarges your cervix and inserts a vacuum-like device that removes most of the tumor. Then, using a long spoon-like instrument, the lining of your uterus is removed to ensure that no molar tissue remains.
Women with other types of GTD may be treated with complete removal of the uterus (hysterectomy). Some women with hydatidiform moles who do not wish to have more children may also choose this option. However, hysterectomy is rarely required.
After surgery, your doctor will measure your HCG level to verify that the mole was completely removed.
Chemotherapy
If your GTD has spread beyond the uterus, your doctor may recommend chemotherapy. Women who have had hydatidiform moles removed and whose tumors persist but have not spread may receive the drugs methotrexate or actinomycin-D, usually as a single weekly dose. Treatment continues until three consecutive HCG tests produce normal results.
Chorioadenomas and choriocarcinomas are both highly responsive to prompt management with newer multidrug regimens. Drugs commonly used to treat these cancers include methotrexate, cyclophosphamide, etoposide, vincristine, and actinomycin-D, given daily or every other day for 5 to 7 days. The drug regimen is repeated after several days or weeks until HCG tests indicate that the disease has gone into remission.
